报告时间:2019年7月3号下午 15:00


杨四海,南京大学生命科学学院教授、博导、副院长;入选第四批国家“万人计划”科技创新领军人才、科技部“创新人才推进计划”中青年科技创新领军人才、教育部“新世纪优秀人才支持计划”。主要从事植物进化遗传学方面的研究工作,并重点在植物突变的产生与保留机制方面取得系列研究进展,发现影响突变产生的一种正反馈机制,即基因组的异质性能促进生物体减数分裂的重组与突变。相关研究分别发表在Nature、Nature Ecol Evol、Nature Plants、PNAS、Genome Biol、Mol Biol Evol、PLOS Biol等领域重要期刊,共计发表研究论文50余篇,引用2000余次,得到同行的广泛关注与积极评价。


  1. Chen J, Hao Z, Guang X, Zhao C, Wang P, Xue L, Zhu Q, Yang L, Sheng Y, Zhou Y, Xu H, Xie H, Long X, Zhang J, Wang Z, Shi M, Lu Y, Liu S, Guan L, Zhu Q, Yang L, Ge S, Cheng T, Laux T, Gao Q, Peng Y, Liu N*, Yang S*, Shi J* (2019) De novo Liriodendron genome sheds light on angiosperm phylogeny and genome differentiation between a vicariad species-pair of East Asia-East North America. Nature Plant5:18–25(IF=13.5)
  2. Wang L, Ji Y, Hu Y, Hu H, Jia X, Jiang M, Zhang X, Zhao L, Zhang Y, Jia Y, Qin C, Yu L, Huang J, Yang S*, Hurst LD* and Tian D*. (2019) The architecture of intra-organism mutation rate variation in plants. PLOS Biol17(4):e3000191(IF5y=9.5)
  3. Chen X, Tian X, Xue L, Zhang X, Yang S*, Traw M*, Huang J*. (2019) CRISPR-based assessment of gene specialization in the gibberellin metabolic pathway in rice. Plant Physiol. 10.1104/pp.19.0032(IF5y=7.0)
  4. Jia X, Zhang Y, Zhang Q, Zhao Q, Wang L, Traw M, Tian D, Wang C*, Yang S*. (2018) High resolution insight into recombination events at the SD1 locus in rice. Plant J (IF5y =6.5)
  5. Liu H, Huang J, Sun X, Li J, Hu Y, Yu L, Liti G, Tian D, Hurst LD*, Yang S*. (2018) Tetrad analysis in plants and fungi finds large differences in gene conversion rates but no GC bias. Nature Ecol Evol 2:164–173 (IF=10.9)
  6. Huang J, Li J, Zhou J, Wang L, Yang S, Hurst LD, Li WS, Tian D*. (2018) Identifying a large number of high-yield genes in rice by pedigree analysis, whole genome sequencing and CRISPR-Cas9 gene knockout. PNAS 115:E7559-E7567(IF=10.5)
  7. Liu H, Jia Y, Sun X, Tian D, Hurst LD*, Yang S*. (2017) Direct determination of the mutation rate in the bumblebee reveals evidence for weak recombination-associated mutation and an approximate rate constancy in insects. Mol Biol Evol 34: 119-130(IF=14.5)
  8. Gu L, Wu Y, Jiang M, Si W, Zhang X, Tian D*, Yang S*. (2016) Dissimilar Manifestation of Heterosis in Super Hybrid Rice at Early-Tillering Stage under Nutrient-Deficient and Nutrient-Sufficient Condition. Plant Physiol172: 1142-1153 (IF5y=7.4)
  9. Xie Z, Wang L, Wang L, Wang Z, Lu, Z, Tian D, Yang S*, Hurst LD.* (2016) Mutation rate analysis via parent-progeny sequencing of the perennial peach I. A low rate in woody perennials and a higher mutagenicity in hybrids. P Roy Soc B-Biol Sci283: 20161016. (IF5y=5.4)
  10. Wang L, Zhang Y, Qing C, Tian D, Yang S*, Hurst LD.* Mutation rate analysis via parent-progeny sequencing of the perennial peach II: No evidence for recombination-associated mutation. P Roy Soc B-Biol Sci 283: 20161785 (IF5y=5.4)
  11. Yang S,Wang L, Huang J, Zhang X, Yuan Y, Chen J-Q, Hurst LD, Tian D* (2015). Parent-progeny sequencing indicates higher mutation rates in heterozygotes. Nature523 :463-467 (IF5y=43.5)
  12. LiuH, Zhang X, Huang J, Chen JQ, Tian D, Hurst LD, Yang S*. (2015) Causes and consequences of crossing-over evidenced via a high-resolution recombinational landscape of the honey bee. Genome Biology 16:15(IF5y=18.5)
  13. Si W, Yuan Y, Huang J, Zhang X, Zhang Y, Zhang Y, Tian D, Wang C, YangYH*, Yang S*. (2015) Widelydistributed hot and coldspots in meiotic recombination as shown by sequencing of rice F2 plants. New Phytologist206 :1491-1502(IF5y =8.3)
  14. Zhang X#, Yang S#, Wang J#, Jia Y#, Huang J#, Zhong Y, Tan S, Wang L, Gu L, Chen JQ, Pan QH*, Bergelson J*, Tian D*. (2015) A genome-wide survey reveals abundant rice blast R-genes in resistant cultivars. Plant J84 :20-28 (IF5y =6.9)
  15. Yang S, Li J, Zhang X, Zhang Q, Huang J, Chen J-Q, Hartl DL, Tian D*. (2013) Rapidly evolving Rgenes in diverse grass species confer resistance to rice blast disease. PNAS110: 18572-18577(IF5y =10.5)
  16. Yang S#, Yuan Y#, Wang L#, Li J, Wang W, Liu H, Chen JQ, Hurst LD, Tian D*. (2012) Great majority of recombination events in Arabidopsis are gene conversion events. PNAS109: 20992–20997 (IF5y =10.5)
  1. Yue J-X, Meyers BC, Chen J-Q, Tian D, Yang S*. (2012) Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes. New Phytologist193: 1049–1063(IF5y =8.3)
  2. Tian D*, Wang Q, Zhang P, Araki H, Yang S, Kreitman M, Nagylaki T, Hudson T, Bergelson J, Chen J. (2008) Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes. Nature455: 105-108